MPC1 and colorectal cancer: Furthermore, it was also reported that overexpression of MPC1 and MPC2 in colorectal cancer cell lines decreased cell growth in spheroids, decreased tumor size in subcutaneous xenografts, and the expressions of the stem cell markers ALDH, Lin28A, LGR5, and NANOG were suppressed in the MPC1 and MPC2 overexpression cells [13].