We found that ATG7 overexpression led to instability of ETS2 mRNA, subsequently increasing miR-196b transcription, further inhibiting FOXO1 mRNA stability by directly targeting its mRNA 3′ UTR, which, in turn, resulted in reduction of p27 transcription and promoted G2/M transition and the tumorigenic growth of human BC. This evidence concerns the gene ETS2 and breast cancer.