The canonical pathway controlling autophagosome formation requires ATG7, which acts as an E1 enzyme and is responsible for the two ubiquitin-like systems required for transport from the cytoplasm to the vacuole and further leading to autophagy.27, 28 In the current study, we define the status and role of ATG7 in the promotion of human BC tumorigenic growth and elucidate the ATG7 downstream effector(s) resulting in the regulation of BC tumorigenic growth. Here, ATG7 is linked to breast cancer.