TP53 and breast cancer: As shown in Figures 2A and 2B, knockdown of ATG7 specifically increased p27 protein abundance with no remarkable effect on the expression of p53, Cyclin A2, Cyclin B1, and CDK2 in both UMUC3 and T24 cells, suggesting that ATG7 overexpression provides an inhibitory effect on p27 expression in BC cells.