In EMILIA clinical trial including 991 patients with HER+ advanced BC, Verma et al. reported that T-DM1 significantly prolonged progression-free and overall survival with less toxicity than lapatinib (tyrosine kinase inhibitor) plus capecitabine (an anti-cancer agent that belongs to fluoropyrimidine family) in patients with HER2+ advanced BC previously treated with trastuzumab and taxanes [64]. This evidence concerns the gene ERBB2 and breast cancer.