Here, we assessed the effects of GPE with respect to its possible mechanisms by determining the XO, Sur, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and the expression level of mUART1, mOAT1 and mGLUT9 in renal were also carried out to comprehensively study the mechanism of G. pensylvanicum against hyperuricemia and gout. This evidence concerns the gene TNF and hyperuricemia.