CD274 and cervical carcinoma: Though the use of anti-PD-1/PD-L1 immunotherapies has not been extensively explored for the treatment of cervical cancer, recent studies have evaluated biologic rationales for PD-L1 expression in the cervical tumors, including its pathogenesis through human papillomavirus (HPV), its tumor microenvironment composed of tumor-infiltrating lymphocytes, as well as its genetic basis for increased expression.