In the proximal colon cancer network, KRAS mutation was negatively correlated with BRAF mutation (ρ = −0.47), MLH1 methylation (ρ = −0.40), MSI-high (ρ = −0.39), RUNX3 methylation (ρ = −0.34), CACNA1G methylation (ρ = −0.32), CRABP1 methylation (ρ = −0.31), IGF2 methylation (ρ = −0.30), loss of CDX2 expression (ρ = −0.29), SOCS1 methylation (ρ = −0.27), CDKN2A methylation (ρ = −0.23), NEUROG1 methylation (ρ = −0.22), and Crohn’s-like reaction (ρ = −0.20). This evidence concerns the gene RUNX3 and colonic neoplasm.