Highly connected biomarkers (with degree centrality) were BRAF mutation (0.19) and methylation-related markers including CDKN2A (0.17), IGF2 (0.17), RUNX3 (0.17), CACNA1G (0.15), CRABP1 (0.15), and NEUROG1 (0.15) in the proximal colon cancer network. Here, RUNX3 is linked to colonic neoplasm.