In the distal colorectal cancer network, MSI was also positively correlated with MLH1 methylation (ρ = 0.35), TIL (ρ = 0.29), RUNX3 methylation (ρ = 0.26), Crohn’s-like reaction (ρ = 0.24), CACNA1G methylation (ρ = 0.23), SOCS1 methylation (ρ = 0.22), intratumoral periglandular reaction (ρ = 0.22), BRAF mutation (ρ = 0.21), and peritumoral lymphocytic reaction (ρ = 0.19). Here, RUNX3 is linked to colorectal cancer.