Since high-grade serous ovarian tumors express higher levels of CA125 than the nonserous mucinous ovarian tumors [43, 44], our finding is consistent with the notions that at least some of the high-grade serous ovarian tumors originate in the fallopian tube and nonserous mucinous tumors might develop from the ovarian surface epithelium or cortical inclusion cysts. Here, MUC16 is linked to ovarian serous tumor.