SOX2 and cancer: SOX2 has been shown to promote the survival of cancer cells in vivo and has been linked to lens cell survival in Astyanax surface fish (Boumahdi et al., 2014; Chou et al., 2013; Herreros-Villanueva et al., 2013; Ma et al., 2014), but a role for SOX2 in cell survival during mammalian organogenesis has not been reported.