These panels include a variable number of genes [4–6] and clear evidence of association with breast cancer is currently available for eleven genes (i.e., BRCA1, BRCA2, TP53, PALB2, PTEN, CHEK2, ATM, NF1, PTEN, STK11, CDH1) [7], supporting the use of this information in clinical genetics services. The gene discussed is PTEN; the disease is breast carcinoma.