Moreover, in agreement with very recent findings which describe, in both cultured cells and in scrapie-infected rodents, disruption of glycosylation and enhancement of Sho proteasomal degradation53, we found that the proteasomal inhibitor ALLN led to the accumulation of immature unglycosylated band of Sho (see also ref. 25). This evidence concerns the gene SPRN and scrapie.