ANGPT1 and myocardial infarction: The possibility that increased sTie2 could contribute to vascular pathology by inhibiting Angpt1 protective signalling has been highlighted in peripheral arterial disease, myocardial infarction, vessel permeability in inflammation, organ failure in post cardiac-arrest syndrome and trauma, pulmonary hypertension, and neoangiogenesis8, 12, 15–19.