A combination of transcriptomic and proteomic data revealed several key candidate regulators (A2M, PDLIM3, CRYAB, and ACE) and pathways (HIF-1 signaling pathway, cardiovascular development, VEGF signaling pathway, and pathways in cancer) that might play high-priority roles in the hypoxic adaptation of Tibetan pigs. This evidence concerns the gene HIF1A and cancer.