A combination of transcriptomic and proteomic data revealed several key candidate regulators (A2M, PDLIM3, CRYAB, and ACE) and pathways (HIF-1 signaling pathway, cardiovascular development, VEGF signaling pathway, and pathways in cancer) that might play high-priority roles in the hypoxic adaptation of Tibetan pigs. The gene discussed is A2M; the disease is cancer.