HIF1A and cancer: Based on functional annotation, 21 DEGs were associated with hypoxia (Table 1), which involved the GO terms of “response to hypoxia”, “blood vessel development”, “response to reactive oxygen species”, “circulatory system process”, “regulation of heart contraction”, and “immune system development”, as well as the HIF-1 signaling pathway, the mitogen-activated protein kinase (MAPK) signaling pathway, pathways in cancer, glycolysis/gluconeogenesis, and the TGF-beta signaling pathway.