In 3 individuals with familial MS (7.9%), 7 individuals with sporadic MS (15.9%) and 9 controls (9.8%), we also identified a set of co-occurring variants: Thr246Ser, Thr878Met, Thr995Ile, Met1119Val in Val1241Leu which corresponded to the autoimmunity-associated haplotype (H3) containing a set of rare missense variants in NLRP1, previously identified and associated with autoimmune diseases (Table 1 and Supplementary Figure 2)8. The gene discussed is NLRP1; the disease is autoimmune disease.