These patients also developed bronchiectasis (11), sepsis (7), and significant other events (21) before adequate prophylactic treatment which included sulfamethoxazole/trimethoprim and fluconazole for T cell deficiency, sulfamethoxazole/trimethoprim, itraconazole, and/or interferon-gamma for polymorphonuclear cell deficiency, regular immunoglobulin infusion for B cell deficiency, and ampicillin-sulbactam for bronchiectasis. The gene discussed is IFNG; the disease is Sepsis.