Similarly, in DM1 and DM2 patients [humans have three MBNL homologous genes: MBNL1-3 (Fardaei et al., 2002)], the sequestration of MBNL proteins in RNA foci reduces the amount of functional MBNL proteins available for proper splicing, resulting in a shift from the normal adult splice pattern to an inappropriate embryonic/fetal pattern of target transcripts (Miller et al., 2000; Mankodi et al., 2001; Jiang et al., 2004; Kanadia et al., 2006; Holt et al., 2009). The gene discussed is MBNL1; the disease is myotonic dystrophy type 2.