For example, aberrant splicing of the muscle-specific chloride channel CLCN1 and the insulin receptor (INSR) accounts for myotonia in DM (Savkur et al., 2001, 2004; Mankodi et al., 2002; Wheeler et al., 2007; Tonevitsky and Trushkin, 2009; Tang et al., 2012; Santoro et al., 2013). The gene discussed is INSR; the disease is Myotonia.