Although Foxp3CreTgfbr2f/f mice did not show overt autoimmune disease, increased percentages of CD44highCD62Llow effector/memory T cells (Fig. 8d) were observed despite a slightly increased Treg cell frequency among CD4+ T cells (Fig. 8e), indicating the functional impairment of TGF-βR2-deficient Treg cells. Here, CD4 is linked to autoimmune disease.