Compared with the control patients, patients with acromegaly had an increased incidence of DM (37.50 vs. 5.26%, p = 0.032) and higher levels of blood glucose (6.24 ± 1.45 vs. 4.78 ± 0.44 mmol/L, p = 0.001), GH (20.49 ± 15.03 vs. 0.45 ± 0.40 ng/ml, p < 0.001), IGF-1 (994.00 ± 281.17 vs. 198.26 ± 110.14 ng/ml, p < 0.001), GH burden (1653.00 ± 1910.72 vs. 31.67 ± 63.33 ng*m/ml, p = 0.004) and IGF-1 burden (79,640.25 ± 55,347.61 vs. 8822.21 ± 12,205.21 ng*m/ml, p < 0.001). Here, IGF1 is linked to diabetes mellitus.