SLCO1A2 and hepatocellular carcinoma: As mentioned above, in addition to typical hemodynamic changes of HCC such as increased arterial flow and decreased portal flow, several pathologic changes can occur during development of HCC, including changes in cellularity, the transporters of hepatocytes such as organic anionic transporting polypeptides (OATP), and a decrease in the number and function of Kupffer cells [218, 227, 229, 254–257].