These studies also demonstrated that procainamide and hydralazine are DNA methylation inhibitors, and that T cells from patients with active lupus have hypomethylated DNA, overexpress the same genes as CD4+ T cells treated with 5-azacytidine, procainamide or hydralazine, and are similarly autoreactive [8]. This evidence concerns the gene CD4 and systemic lupus erythematosus.