Lupus-like autoantibodies such as anti-nuclear antibodies as well as anti-Sm, anti-Ro, anti-La and anti-cardiolipin, and occasionally clinical features of lupus, can also be found in patients with other chronic autoimmune diseases characterized by inflammation and oxidative stress such as Sjogren’s syndrome, rheumatoid arthritis, systemic sclerosis, and overlap syndromes [2–6]. This evidence concerns the gene SSB and systemic lupus erythematosus.