The aim of this study was to determine the possible predictive role of serum NGAL as a supplementary marker to urinary albumin excretion, in unmasking early renal structural injury, renal function decline, and cardiovascular risk in asymptomatic, normotensive individuals in two different age groups, childhood and adulthood, with various duration of T1D and irrespective of the presence of microalbuminuria. This evidence concerns the gene LCN2 and type 1 diabetes mellitus.