In disease models, absence of Gal-9 results in increased eosinophilia and Th2 cells but low Foxp3+ Tregs while administration of Gal-9 causes an attenuated asthmatic response attributable to induction of endogenous Gal-9 and direct interaction of Gal-9 with CD44 (limiting leukocyte adhesion and migration and promoting stability and function of iTregs). Here, LGALS9 is linked to Increased total eosinophil count.