Other known Gal-1 effects that could potentially have a beneficial effect during chronic asthma include induction of IL-10 production by T cells (81, 82) [required for regulatory T cell (Treg)-mediated inhibition of airway inflammation in asthma], supporting inhibitory function of Tregs (83), and suppression of inflammatory cytokine [TNFα and interferon γ] release by T cells (84). This evidence concerns the gene LGALS1 and asthma.