LGALS9 and airway hyperresponsiveness: Most recently, in a study designed to test the efficacy of Gal-9 as an adjuvant to allergen-specific sublingual immunotherapy in a mouse model of chronic asthma, administration of Gal-9 was found to inhibit eosinophilic airway inflammation, airway hyperresponsiveness, and allergen-specific IgE while inducing transforming growth factor β-1 production as well as the number of CD4+CD25+Foxp3high Tregs in the BALF, thus suggesting that using Gal-9 as an adjuvant to sublingual immunotherapy may be a more effective treatment option (116).