As detailed in this review, Gal-3 plays a pro-inflammatory role in allergic asthma by promoting eosinophil trafficking and migration, while Gal-1 exerts an anti-inflammatory effect due to its ability to limit eosinophil migration and induce apoptosis, wherein decreased expression or absence of this galectin results in increased eosinophilia and exacerbated asthmatic immune responses. The gene discussed is LGALS3; the disease is Increased total eosinophil count.