Criteria for OB-APS include three or more early (<10 weeks) pregnancy losses, fetal loss or stillbirth, or delivery at less than 34 weeks in women who have documented persistent aPL whether lupus anticoagulant (LAC), high titer IgG or IgM anticardiolipin (aCL) or high titer IgG or IgM anti-β2 Glycoprotein I (aβ2GPI) [41]. This evidence concerns the gene CD40LG and autoimmune polyendocrinopathy.