A 3-month intervention with a synbiotic formula combining the above-mentioned prebiotic scGOS/lcFOS (9:1) mixture with Bifidobacterium breve M-16V, which has potential anti-allergic properties(17), showed a reduction of the SCORing Atopic Dermatitis (SCORAD) score in infants with IgE-mediated atopic eczema as well as a positive modulation of the gut microbiota(18). This evidence concerns the gene IGHE and atopic eczema.