This intriguing result suggests that either IgG ASCs induced by malaria challenge are not cognate for MSP1 (unlike ASCs induced by vaccination, and despite this being a dominant antigen for inducing IgG memory B cell responses), or that malaria infection downregulates the normal ASC response to infection, or that the timing of the malaria-specific ASC response differs to that of other acute infections. Here, ATAD1 is linked to infection.