Among them we can mention the addition of a peptide vaccine to high-dose interleukin-2 (IL-2) (17), the use of a GM-CSF secreting tumor vaccine in combination with CTLA-4 blockade for metastatic prostate cancer (18), and the use of an autologous vaccine plus Bacillus Calmette–Guerin (BCG) that showed an increased response rate with subsequent ipilimumab for progressive disease in stage III melanoma pts (19). This evidence concerns the gene CTLA4 and neoplasm.