TWEAK and Fn14 activate in kidneys of mice with LN, contributing to glomerular and interstitial fibrosis by promoting the production of TGF-β1, monocyte chemotactic protein-1, interferon gamma-induced protein 10, and chemokine (C–C motif) ligand 5 (33, 38, 39). The gene discussed is TNFRSF12A; the disease is lobular neoplasia.