IL6 and neoplasm: Although the precise molecular mechanism and specific different constituents are unknown, these data suggest that malignant cells secreted exosomes in the tumor microenvironment to recruit lymphocytes not only to suppress antitumor immunity (IL6, Foxp3, and HLA-A/B) but also to enhance tumor invasion, tumor angiogenesis, and dissemination of proinflammatory cytokines (such as IL6 and VEGFA).