Induction of inflammation at the site of autoantibody binding: autoantibodies against structural proteins of the skin in PD, or autoantibodies targeting myosin in myocarditis or autoantibodies recognizing citrullinated proteins in rheumatoid arthritis (RA) or autoantibodies targeting aquaporin-4 (AQP4) in neuromyelitis optica (NMO). This evidence concerns the gene AQP4 and rheumatoid arthritis.