Data from mice models show that anti-AT1R and anti-ETAR antibody-positive SSc-IgG cause structural alterations of the lungs including induction of interstitial lung disease and obliterative vasculopathy, increased cellular density, and enhanced interstitial cellular infiltrations following passive transfer of IgG from SSc patients to wild-type mice (134, 135). The gene discussed is EDNRA; the disease is systemic sclerosis.