Further evidence for direct interference with adhesion comes from epitope-mapping studies of pemphigus autoantibodies on domain-swapped and point-mutated Dsg1/Dsg3 molecules, mapping most of the dominant epitopes bound by patients’ sera to the aminoterminal ectodomains of Dsg1/3, which are critical for adhesion (262). Here, DSG3 is linked to pemphigus.