Anti-AT1R and anti-ETAR are strong predictors of digital ulcers development (131), they can be considered as predictive and prognostic biomarkers of (SSc)-associated pulmonary arterial hypertension (132) and are linked to the development of lung fibrosis and vasculopathies in patients with SSc (133). The gene discussed is EDNRA; the disease is pulmonary fibrosis.