DSG1 and pemphigus: Multiple lines of evidence exist for the finding, that the main antigens targeted in pemphigus are desmogleins (Dsgs), desmosomal transmembrane glycoproteins that mediate epidermal cell–cell adhesion, and different expression (and compensation) of Dsg3 and Dsg1 within epidermis and mucous membranes explains the localization of blisters in PV and PF patients (235, 240, 241).