In detail, PCOS patients with an elevated LH/FSH ratio had a better pregnancy rate when treated with GnRH agonist protocols than with GnRH antagonist protocols, probably because the long GnRH agonist induces prolonged LH suppression milieu thereby avoiding the negative effect of higher LH levels on reproductive outcome (21, 23, 24). Here, PLOD1 is linked to polycystic ovary syndrome.