IL18 and relapsing-remitting multiple sclerosis: Dendritic cells form SPMS patients secret much higher levels of IL-18 than those from RRMS patients and healthy controls (43) and induce—in vitro—solely a Th1 cell response not Th1 and Th2 like in RRMS suggesting a role of dendritic cells in the disease transition into the progressive phase (44).