WNT2 and central nervous system cancer: Overexpression of WNT1 and WNT3a in glioma stem cells has been shown in the malignant transformation and progression of high-grade gliomas (Zhang J. et al., 2011; Riganti et al., 2013; Denysenko et al., 2016), WNT2 and WNT5 are also overexpressed in glioma.