The aberrant activation of canonical WNT/beta-catenin pathway contributes to glioma development and malignant progression (Utsuki et al., 2002; Sareddy et al., 2009; Yang et al., 2010; Liu X. et al., 2011; Schule et al., 2012; Yang C. et al., 2012), invasion (Kahlert et al., 2012), and prognostic implications (Liu C. et al., 2011; Rossi et al., 2011; Shi et al., 2012). The gene discussed is CTNNB1; the disease is central nervous system cancer.