BDNF and major depressive disorder: BDNF transcription factors NF-κB and AP-1 are sensitive to oxidative and nitrosative status (Kamata et al., 2002; Parohova et al., 2009) and have been implicated to play a role in the pathogenesis of neuropsychiatric disorders, including schizophrenia and depression (Altinoz et al., 2016; Ménard et al., 2016).