↓ Anxiety (↑ time spent in the open arms of EPM) in ♂↑ AVP mRNA expression in PVN in ♀↓ Orexin mRNA expression in PVN in ♂= Basal plasma ACTH levels↑ Stress-induced plasma corticosterone levels in ♀↓ Stress-induced plasma corticosterone levels in ♂. The gene discussed is AVP; the disease is Anxiety.