A complete loss of activity of the mitochondrial glutamate carrier 1 (GC1, SLC25A22) has been associated with early epileptic encephalopathy (EEE; Molinari et al., 2005, 2009; Cohen et al., 2014) and migrating partial seizures in infancy (MPSI; Poduri et al., 2013), but, to the best of our knowledge, no animal model has been developed for this human pathology. The gene discussed is SLC25A22; the disease is eastern equine encephalitis.