Specifically, polymorphisms in the NaV1.4 (SCN4A-rs2302237) and NaV1.8 genes (SCN10A-rs1263292) have been associated with increased incidence of acute oxaliplatin-induced neuropathy (Argyriou et al., 2013a), while patients carrying a polymorphism (rs6746030) in the SCN9A gene encoding for NaV1.7 seem to develop less severe neuropathy than patients carrying other SCN9A gene variants (Sereno et al., 2017). This evidence concerns the gene SCN10A and neuropathy.