Correspondingly, functional disease ontology analysis showed that genes related to “Alzheimer's disease” and “Schizophrenia” were enriched (Table 1), and that those related to schizophrenia (Hess et al., 2016; Wu et al., 2016b) indeed possessed Otx2-binding sites around the TSS (Table S1). Here, OTX2 is linked to early-onset autosomal dominant Alzheimer disease.