For those PCOS women with both biochemical hyperandrogenism (including those with a raised salT) and clinical hyperandrogenism versus clinical hyperandrogenism alone, women with PCOS and both biochemical and clinical hyperandrogenism had a more metabolic phenotype with higher insulin and insulin resistance levels that may have reflected the greater BMI, waist and hip circumference rather than being a specific and distinct PCOS subtype. The gene discussed is INS; the disease is hyperandrogenism.