Analysis of EZH2 mRNA expression data from TCGA database and GEO portal revealed that EZH2 was significantly up-regulated in ovarian cancer compared with normal controls (Supplemental Fig. S1a–d) and high EZH2 expression was related to advanced FIGO stage, poor differentiation, and metastasis (Table 1). This evidence concerns the gene EZH2 and ovarian carcinoma.