PTPN22 and hematologic disorder: However, in the independent validation cohort, only the association between PTPN22 and hematologic disorder (PReplication = 0.043,PCombined = 8.25e-4) and between PTPN22 and the production of antinuclear antibodies (PReplication = 0.028,PCombined = 0.001) were significantly replicated.