Another gene suggested to be a genetic risk factor for BPD is represented by Catechol-O-methyltransferase (COMT), an enzyme catalyzing the degradation of catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine; however, literature data on the role of this gene are contrasting. The gene discussed is COMT; the disease is Borderline personality disorder.