Interestingly, genes involved in the PI3K‐AKT‐mTOR pathway, such as PIK3CA, had a higher proportion of subclonal events compared to genes associated with RAS‐MAPK pathway, including KRAS, NRAS, and BRAF. There were clear differences in clonality of PIK3CA and BRAFV600E events according to tumor type, and we also identified a more clonal distribution in breast cancer and melanoma, respectively, as compared with CRC. Here, PIK3CA is linked to melanoma.