TP53 and colorectal carcinoma: A stratified analysis based on tissue source (Fig. S1C) showed TP53 adjMAFs significantly higher in metastases (median 0.76, IQR 0.51–1.00; n = 63) than CRC primaries (median 0.60, IQR 0.38–0.83; n = 126; P = 0.005; Fig. 1G), suggesting that TP53 copy number alterations are more frequent in CRC metastases.