INS and type 2 diabetes mellitus: In the present study we performed ultrastructural and immunocytochemistry evaluations of pancreatic samples from 12 non-diabetic (ND) and 12 matched T2D multiorgan donors to show the presence of cells containing both acinar cell markers and insulin, that were more frequent in the pancreas of subjects with T2D, suggesting that transition from one cell type to the other could occur in vivo.