The subgroup of T2D donors showing pancreatic cells double positive for acinar and endocrine (insulin) markers at the electron microscopy analyses had similar age (70±2.9 vs 67.6±3.27 yrs), BMI (26.7±0.48 vs 27.5±1.2 kg/m2) and known duration of diabetes (14.2±5.5 vs 11.1±2.2 yrs) as the subgroup of T2D individuals in whom this type of cells was not observed. Here, INS is linked to diabetes mellitus.