The allele frequency of RNF213 p.Arg4810Lys was significantly higher in MMD patients than in the 622 controls (33.90% in the MMD group versus 0.80% in the control group; P<0.0001) and in the 1100 controls (33.90% in the MMD group versus 1.05% in the control group; P<0.0001). Here, RNF213 is linked to multiminicore myopathy.