Overall, our findings are in agreement with previous studies demonstrating that GHRH analogues restore physiologic GH and IGF-1 levels without inducing insulin resistance and/or hyperglycemia in various populations, including healthy middle-aged and elderly subjects [5, 7, 8], GH-deficient children [19], and patients with HIV-associated lipodystrophy [6]. This evidence concerns the gene GHRH and lipodystrophy.