Both siblings with severe liver injuries (highly at risk of developing liver cirrhosis and cirrhosis/transplantation) carried these two SNPs (Herp R50H/rs2217332; c.G149A; p.R50H and HFE H63D/rs1799945 c.C187G; p.H63D) (Table 1), strongly suggesting their contribution to liver damages progression associated with 1ATD. Here, HFE is linked to Cirrhosis.