CDC20 and cancer: Studies suggest that Cdc20 is frequently overexpressed in many of the higher grades of cancer.16, 17, 25, 26, 27 Moreover, selective depletion of Cdc20 leads to the inhibition of tumor growth and metastasis.28 Previous reports revealed that SMAR1 expression was ablated in higher grades of breast cancer.4 Therefore, the elevated levels of Cdc20 in higher grades of cancer could be associated with lower SMAR1 expression.