Recent studies have demonstrated that CTGF could confer resistance to chemotherapeutic agents in a variety of cancers.10, 11, 12, 13 Moreover, in our previous microarray analysis, we also found CTGF upregulated in the TMZ-resistant U87 cells.23 However, whether the deregulated CTGF expression correlated to the glioma tumor grades and the tumor grades-related multidrug resistance (MDR) phenotype are still not clear. The gene discussed is CCN2; the disease is central nervous system cancer.