IL22 and Hepatic fibrosis: Krizhanovsky et al. showed that senescent activated HSCs reduced the secretion of ECM components, enhanced immune surveillance, and facilitated the reversion of fibrosis.40 Kong et al. also reported that interleukin-22 induced HSC senescence and restricted liver fibrosis in mice.41 Consistent with previous studies,40, 41 we showed that the senescence of activated HSCs induced by DHA treatment provide a brake on the fibrogenic response to damage by limiting the expansion of the cell type responsible for producing the fibrotic scar.