GSK3A and Alzheimer disease: It has been reported that lithium prevents the generation of Aβ peptides by inhibiting GSK3α activity, which interferes with APP γ-secretase cleavage.14, 33, 34 In terms of LP, we expected that addition of salicylate, which is the primary metabolite derivative of acetyl-salicylic acid (aspirin), could work together synergistically to improve the safety and modify the pharmacological action of lithium for attenuating AD pathology.