PPIB and Alzheimer disease: Lithium treatment has been shown to reduce Aβ generation in vitro,14 whereas controversial results also exist regarding its ability to reduce Aβ production in vivo.23, 24 We determined the effect on β-amyloid plaques by chronic treatment with LC or LP in Tg2576 mice and with LC, LS, or LP in 3XTg-AD mice.