14 Lithium also blocks the accumulation of Aβ in brains of mice overexpressing APP by inhibition of GSK3β, implicating its requirement for maximal processing of APP.15 As GSK3β also phosphorylates tau protein, inhibition of GSK3β offers a new approach to reduce the formation of both β-amyloid plaques and NFTs. This evidence concerns the gene MAPT and amyloidosis.