It has been shown that acute and chronic administration of lithium could enhance COX2 expression by suppressing GSK3β activity in renal cell lines and mouse models.29, 30 We observed the effect of LISPRO on COX2 expression in renal cells from the Tg2576 AD as well as wild-type B6129SF2/J mouse models. The gene discussed is GSK3B; the disease is Alzheimer disease.