SQSTM1 and cancer: Emerging evidences suggest that when autophagy is impaired, p62 accumulates in the cytosol and tends to competitively bind with Keap1, a negative regulator of Nrf2, resulting in prolonged Nrf2 activation,40, 41, 42 and that dysregulation of Nrf2 signaling pathway is able to promote cell proliferation and chemoresistance in several cancers.43, 44, 45, 46 In this study, we observed an autophagic flux and nuclear translocation of Nrf2 in the cells treated with ESI (Figures 2,3,4 and 5).