BST2 has also previously been reported to restrict HIV infection by activating the NF-κB pathway,27 and activation of the NF-κB pathway has been shown to attenuate apoptosis by upregulating the expression of anti-apoptotic factors.23, 24, 25, 26, 28, 29 Therefore, we hypothesized that BST2 confers cisplatin resistance by activating NF-κB signaling. This evidence concerns the gene NFKB1 and HIV infectious disease.